2004

Bioinorganic Chemistry, Some Fragmentary Comments
H. Sigel
Russian Chemistry Journal 48, 4-5 (2004) – Translated by Professor Elena Milaeva and published in Russian as an invited contribution to the special Bioinorganic Chemistry issue of the Russian Chemistry Journal

Acid-Base Properties of Xanthosine 5'-Monophosphate (XMP) and of Some Related Nucleobase Derivatives in Aqueous Solution. Micro-Acidity-Constant Evaluations of the (N1)H versus the (N3)H Deprotonation Ambiguity
S. S. Massoud, N. A. Corfù, R. Griesser, and H. Sigel
Chem. Eur. J. 10, 5129-5137 (2004)

Intramolecular Stacking Interactions in Ternary Copper(II) Complexes Formed by a Heteroaromatic Amine and 9-[2-(2-Phosphonoethoxy)ethyl]adenine (PEEA), a Relative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) (Ternary Complexes in Solution. Part 67)
A. Fernández-Botello, A. Holý, V. Moreno, and H. Sigel
J. Inorg. Biochem. 98, 2114-2124 (2004)

Quantification of Isomeric Equilibria Formed by Metal Ion Complexes of 8-[2-(Phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(Phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)
R. B. Gómez-Coca, L. E. Kapinos, A. Holý, R. A. Vilaplana, F. González-Vílchez, and H. Sigel
J. Biol. Inorg. Chem. 9, 961-972 (2004)

Review

Acid-base Properties of Purine Residues and the Effect of Metal Ions. Quantification of Rare Nucleobase Tautomers
H. Sigel
Pure Appl. Chem. 76, 1869-1886 (2004)

A Quantitative Appraisal of the Ambivalent Metal Ion Binding Properties of Cytidine in Aqueous Solution
B. Knobloch and H. Sigel
J. Biol. Inorg. Chem. 9, 365-373 (2004) – Dedicated to Professor Liang-Nian Jion the occasion of his 70th birthday

(a) Zwei Metallionen behindern sich kaum bei der Koordination an ein Purin
B. Knobloch, R. K. O. Sigel, B. Lippert, und H. Sigel
Angew. Chemie 116, 3881-3883 (2004)
(b) Two Metal Ions Coordinated to a Purine Residue Tolerate Each Other Well!
B. Knobloch, R. K. O. Sigel, B. Lippert, and H. Sigel
Angew. Chemie Int. Ed. 43, 3793-3795 (2004)

Perturbation of the N₆H₂ pK_a of Adenine in Pt(II) Complexes: Distinct Stereo-chemical Internucleobase Effects
M. Garijo Añorbe, M. S. Lüth, M. Roitzsch, M. Morell Cerdà, P. Lax, G. Kampf, H. Sigel, and B. Lippert
Chem. Eur. J. 10, 1046-1057(2004) – Dedicated to Professor Jan Reedijkon the occasion of his 60th birthday

Review

Adenosine 5'-Triphosphate (ATP^4-). Aspects of the Coordination Chemistry of a Multi-Talented Biological Substrate
H. Sigel
Pure Appl. Chem. 76, 375-388 (2004)

Review

Metal Ion Complexes of Antivirally Active Nucleotide Analogues. Conclusions Regarding Their Biological Action
H. Sigel
Chem. Soc. Rev. 33, 191-200 (2004)

Nickel(II), Copper(II) and Zinc(II) Complexes of 9-[2-(Phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-Aza Derivative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA). Quantification of Four Isomeric Species in Aqueous Solution
R. B. Gómez-Coca, A. Holý, R. A. Vilaplana, F. González-Vílchez, and H. Sigel
Bioinorg. Chem. Appl. 2, 331-352 (2004)

Metal Ion-Binding Properties of (1H-Benzimidazol-2-yl-methyl)phosphonate (Bimp^2-) in Aqueous Solution. Isomeric Equilibria, Extent of Chelation, and a New Quantification Method for the Chelate Effect
M. J. Sánchez-Moreno, A. Fernández-Botello, R. B. Gómez-Coca, R. Griesser, J. Ochocki, A. Kotynski, J. Niclós-Gutiérrez, V. Moreno, and H. Sigel
Inorg. Chem. 43, 1311-1322 (2004)

2003

Solution Structures of Binary and Ternary Metal Ion Complexes of 9-(5-Phosphonopentyl)adenine (3'-deoxa-PEEA). A Nucleotide Analogue Related to the Antivirally Active 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)
R. B. Gómez-Coca, A. Holý, R. A. Vilaplana, F. González-Vílchez, and H. Sigel
Eur. J. Inorg. Chem., 2937-2947 (2003)

Synthesis and Acid-Base Properties of (1H-Benzimidazol-2-yl-methyl)phosphonate (Bimp^2-). Evidence for Intramolecular Hydrogen-Bond Formation in Aqueous Solution Between (N-3)H and the Phosphonate Group
M. J. Sánchez-Moreno, R. B. Gómez-Coca, A. Fernández-Botello, J. Ochocki, A. Kotynski, R. Griesser, and H. Sigel
Org. Biomol. Chem. 1, 1819-1826 (2003)

Complex Formation of Divalent Metal Ions with Uridine 5'-O-Thiomonophosphate (UMPS^2-) or Methyl Thiophosphate (MeOPS^2-). Comparison of Complex Stabilities with Those of the Parent Ligands
C. P. Da Costa, A. Okruszek, and H. Sigel
ChemBioChem 4, 593-602 (2003)

Acid-Base and Metal Ion-Binding Properties of Guanylyl(3'→5')guanosine (GpG^-) and 2'-Deoxyguanylyl(3'→5')-2'-Deoxyguanosine [d(GpG)^-]
C. P. Da Costa and H. Sigel
Inorg. Chem. 42, 3475-3482 (2003)

Stability and Structure of Binary and Ternary Metal Ion Complexes in Aqueous Solution of the Quaternary 1-(2-Phosphonomethoxy)ethyl Derivative of 2,4-Diaminopyrimidine (PMEDAPy^-). Properties of an Acyclic Nucleotide Analogue
A. Fernández-Botello, A. Holý, V. Moreno, and H. Sigel
Polyhedron 22, 1067-1076 (2003)

Stability Constants of Metal Ion Complexes Formed with N3-Deprotonated Uridine in Aqueous Solution
B. Knobloch, C. P. Da Costa, W. Linert, and H. Sigel
Inorg. Chem. Commun. 6, 90-93 (2003)https://doi.org/10.1016/S0162-0134(03)80769-9

Metal Ion Complexes of Nucleoside 5'-O-Thiomonophosphates and Related Ligands. Quantification of the Extent of Metal Ion-Sulfur Binding
H. Sigel
J. Inorg. Biochem. 96, 229 (2003)

Stabilities and Isomeric Equilibria in Aqueous Solution of Monomeric Metal Ion Complexes of Adenosine 5'-Diphosphate (ADP^3-) in Comparison with Those of Adenosine 5'-Monophosphate (AMP^2-)
E. M. Bianchi, S. A. A. Sajadi, B. Song, and H. Sigel
Chem. Eur. J. 9, 881-892 (2003)

Intrinsic Acid-Base Properties of Purine Derivatives in Aqueous Solution and Comparison of the Acidifying Effects of Platinum(II) Coordinated to N1 or N7: Acidifying Effects are Reciprocal and the Proton 'Outruns' Divalent Metal Ions
R. Griesser, G. Kampf, L. E. Kapinos, S. Komeda, B. Lippert, J. Reedijk, and H. Sigel
Inorg. Chem. 42, 32-41 (2003)

2002

Acid-Base and Metal Ion-Binding Properties of Pyridine-Type Ligands in Aqueous Solution. Effect of orthoSubstituents and Interrelation Between Complex Stability and Ligand Basicity
L. E. Kapinos and H. Sigel
Inorg. Chim. Acta 337, 131-142 (2002) – Invited contribution to the ICA issue dedicated to Prof. Dr. Karl E. Wieghardton the occasion of his 60th birthday

Comparison of the Acid-Base Properties of Purine Derivatives in Aqueous Solution. Determination of Intrinsic Proton Affinities of Various Basic Sites
G. Kampf, L. E. Kapinos, R. Griesser, B. Lippert, and H. Sigel
J. Chem. Soc., Perkin Trans. 2, 1320-1327 (2002)

Metal-Ion Binding Properties of O-Phosphonatomethylcholine (PMCh^-). Effects of the Positive Charge of a Distant Trimethylammonium Group on the Coordinating Qualities of a Phosph(on)ate Group
A. Fernández-Botello, R. B. Gómez-Coca, A. Holý, V. Moreno, and H. Sigel
Inorg. Chim. Acta 331, 109 -116 (2002) – Invited contribution to the ICA issue dedicated to Prof. Dr. Geoffrey Sykes

Stabilities of Lead(II) Complexes Formed in Aqueous Solution with Methyl Thiophosphate (MeOPS^2-), Uridine 5'-O-thiomonophosphate (UMPS^2-) or Adenosine 5'-O-thiomonophosphate (AMPS^2-)
C. P. Da Costa, D. Krajewska, A. Okruszek, W. J. Stec, and H. Sigel
J. Biol. Inorg. Chem 7,405 - 415 (2002) – Dedicated to Prof. Dr. Lothar Beyeron the occasion of his 65th birthday

2001

Stabilities and Isomeric Equilibria in Solution of Monomeric Metal Ion Complexes of Guanosine 5'-Triphosphate (GTP^4-) and Inosine 5'-Triphosphate (ITP^4-) in Comparison with Those of Adenosine 5'-Triphosphate (ATP^4-)
H. Sigel, E. M. Bianchi, N. A. Corfù, Y. Kinjo, R. Tribolet, and R. Bruce Martin
Chem. Eur. J. 7, 3729-3737 (2001)

Properties of the Magnesium(II) and Calcium(II) Complexes of 5-and 6-Uracilmethylphosphonate (5Umpa^2- and 6Umpa^2-) in Aqueous Solution
C. F. Moreno-Luque, R. Griesser, J. Ochocki, and H. Sigel
Zeitschr. Anorgan. Allg. Chemie 627, 1882-1887 (2001) – Invited contribution to the issue dedicated to Prof. Eberhard Hoyeron the occasion of his 70th birthday

Comparison of the Acid-Base Properties of 5-and 6-Uracilmethylphosphonate (5Umpa^2- and 6Umpa^2-) and Some Related Compounds.Evidence for Intramolecular Hydrogen-Bond Formation in Aqueous Solution Between (N1)H and the Phosphonate Group of 6Umpa^2-
C. F. Moreno-Luque, E. Freisinger, B. Costisella, R. Griesser, J. Ochocki, B. Lippert, and H. Sigel
J. Chem. Soc., Perkin Trans. 2, 2005-2011 (2001)

Acid-Base Properties of the 5'-Triphosphates of Guanosine and Inosine (GTP^4- and ITP^4-) and of Several Related Nucleobase Derivatives
H. Sigel, E. M. Bianchi, N. A. Corfù, Y. Kinjo, R. Tribolet, and R. B. Martin
J. Chem. Soc., Perkin Trans. 2, 507-511 (2001)

Review

Interactions of Lead(II) with Nucleotides and Their Constituents
H. Sigel, C. P. Da Costa, and R. B. Martin
Coord. Chem. Rev. 219-221, 435-461 (2001) – Dedicated to Prof. A. B. P. Leveron the occasion of his 65th birthday

Metal Ion-Binding Properties of 1-Methyl-4-aminobenzimidazole (= 9-Methyl-1,3-dideazaadenine) and 1,4-Dimethylbenzimidazole (= 6,9-Dimethyl-1,3-dideazapurine). Quantification of the Steric Effect of the 6-Amino Group on Metal Ion Binding at the N7 Site of the Adenine Residue
L. E. Kapinos, A. Holý, J. Günter, and H. Sigel
Inorg. Chem. 40, 2500-2508 (2001)

Formation of Ternary Complexes by Coordination of (Diethylenetriamine)Platinum(II) to N1 or N7 of the Adenine Moiety of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA). Comparison of the Acid-Base and Metal Ion-Binding Properties of PMEA, (Dien)Pt(PMEA-N1) and (Dien)Pt(PMEA-N7)
G. Kampf, M. S. Lüth, L. E. Kapinos, J. Müller, A. Holý, B. Lippert, and H. Sigel
Chem. Eur. J. 7,1899-1908 (2001)

Intramolecular Stacking Interactions in Ternary Copper(II) Complexes Formed with 2,2'-Bipyridine or 1,10-Phenanthroline and 9-(4-Phosphonobutyl)adenine (dPMEA), the Carba Relative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) (Ternary Complexes in Solution. Part 65)
R. B. Gómez-Coca, L. E. Kapinos, A. Holý, R. A. Vilaplana, F. González-Vílchez, and H. Sigel
J. Inorg. Biochem. 84, 39-46 (2001)

2000

Ternary Copper(II) Complexes in Solution Formed with 8-Aza Derivatives of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) (Ternary Complexes in Solution. Part 66)
R. B. Gómez-Coca, L. E. Kapinos, A. Holý, R. A. Vilaplana, F. González-Vílchez, and H. Sigel
Metal Based Drugs 7, 313-324 (2000) – Dedicated to the memory of Prof. Marc Leng

Review

Metal Ions in Environment and Biology
H. Sigel and A. Sigel
J. Indian Chem. Soc. 77, 501-509 (2000) – Invited contribution in the context of the Opening Plenary Lecture delivered at the Platinum Jubilee Celebration of the Indian Chemical Society

Properties of the Ternary (Dien)Pt(PMEA-N7) Complex Containing Diethylenetriamine (Dien) and the Antiviral 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA). Synthesis, Biological Screening, Acid-Base Behaviour, and Metal Ion-Binding in Aqueous Solution
G. Kampf, M. S. Lüth, J. Müller, A. Holý, B. Lippert, and H. Sigel
Z. f. Naturforsch. 55b, 1141-1152 (2000)

Lead(II)-Binding Properties of the 5'-Monophosphates of Adenosine (AMP^2-), Inosine (IMP^2-) and Guanosine (GMP^2-) in Aqueous Solution. Evidence for Nucleobase-Lead(II) Interactions
C. P. Da Costa and H. Sigel
Inorg. Chem. 39, 5985-5993 (2000)

Metal Ion-Binding Properties of 9-(4-Phosphonobutyl)adenine (dPMEA), a Sister Compound of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA), and Quantification of the Equilibria Involving Four Cu(PMEA) Isomers
R. B. Gómez-Coca, L. E. Kapinos, A. Holý, R. A. Vilaplana, F. González-Vílchez, and H. Sigel
J. Chem. Soc., Dalton Trans., 2077-2084 (2000)

Review

Quantification of Isomeric Equilibria for Metal Ion Complexes Formed in Solution by Phosphate or Phosphonate Ligands with a Weakly Coordinating Second Site
H. Sigel and L. E. Kapinos
Coord. Chem. Rev. 200-202, 563-594 (2000) – Invited contribution to the Special CCR 200-2000 issue

Intramolecular Chelate Formation Involving the Carbonyl Oxygen of Acetyl Phosphate or Acetonylphosphonate in Mixed Ligand Copper(II) Complexes Containing also 2,2'-Bipyridine or 1,10-Phenanthroline. A Decreased Solvent Polarity Favours Metal Ion-Carbonyl Oxygen Recognition (Ternary Complexes in Solution. Part 64)
C. P. Da Costa, B. Song, F. Gregán, and H. Sigel
J. Chem. Soc., Dalton Trans., 899-904 (2000)

Intramolecular Stacking Interactions in Mixed Ligand Complexes Formed by Copper(II), 2,2'-Bipyridine or 1,10-Phenanthroline, and Monoprotonated or Deprotonated Adenosine 5'-Diphosphate (ADP^3-). Evaluation of Isomeric Equilibria
E. M. Bianchi, S. A. A. Sajadi, B. Song, and H. Sigel
Inorg. Chim. Acta 300-302, 487-498 (2000) – Invited contribution to this Special ICA-2000 issue

Evaluation of Intramolecular Equilibria in Complexes Formed Between Substituted Imidazole Ligands and Nickel(II), Copper(II) or Zinc(II)
H. Sigel, A. Saha,N. Saha, P. Carloni, L. E. Kapinos, and R. Griesser
J. Inorg. Biochem. 78, 129-137 (2000)

Isomeric Equilibria in Aqueous Solution Involving Aromatic Ring Stacking in the Sexternary Complexes Formed by the Quaternary cis-(NH3)2Pt(2'-deoxyguanosine-N7)(dGMP-N7) Complex and the Binary Cu(2,2'-Bipyridine)²⁺or Cu(1,10-Phenanthroline)²⁺ Complexes (dGMP^2- = 2'-Deoxyguanosine 5'-Monophosphate)
M. S. Lüth, B. Song, B. Lippert, and H. Sigel
Inorg. Chem. 39, 1305-1310 (2000)

Metal Ion-Carbonyl Oxygen Recognition in Complexes of Acetyl Phosphate
H. Sigel and C. P. Da Costa
J. Inorg. Biochem. 79, 247-251 (2000)

1999

Review

Metal Ion-Binding Properties of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)-ethyl]adenine (PMEA). Why is Its Diphosphorylated Form, PMEApp^4-, Initially a Better Substrate for Nucleic Acid Polymerases than (2'-Deoxy)adenosine 5'-Triphosphate (dATP^4-/ATP^4-)?
H. Sigel
Pure Appl. Chem. 71, 1727-1740 (1999)

Aspects of the Co-ordination Chemistry of the Antiviral Nucleotide Analogue, 9-[2-(Phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP)
C. A. Blindauer, T. I. Sjåstad, A. Holý, E. Sletten, and H. Sigel
J. Chem. Soc., Dalton Trans., 3661-3671 (1999)http://http://

Metal Ion-Binding Properties of the Diphosphate Ester Analogue, Methylphosphonylphosphate, in Aqueous Solution
B. Song, J. Zhao, F. Gregáň, N. Prónayová, S. A. A. Sajadi, and H. Sigel
Metal Based Drugs 6, 321-328 (1999)ttps://doi.org/10.1007/s007750050336

Stabilities of Complexes Formed between Lead(II) and Simple Phosphonate or Phosphate Monoester Ligands Including Some Pyrimidine-Nucleoside 5'-Monophosphates (CMP^2-, UMP^2-, dTMP^2-)
C. P. Da Costa and H. Sigel
J. Biol. Inorg. Chem. 4, 508-514 (1999)

Stability and Structure of Metal Ion Complexes Formed in Solution with Acetyl Phosphate and Acetonylphosphonate: Quantification of Isomeric Equilibria
H. Sigel, C. P. Da Costa, B. Song, P. Carloni, and F. Gregáň
J. Am. Chem. Soc. 121, 6248-6257 (1999)

On the Metal-Ion-Coordinating Properties of the Benzimidazolate Residue in Aqueous Solution –Extent of Acidification of Benzimidazole-(N3)H Sites by (N1)-Coordinated Divalent Metal Ions
L. E. Kapinos and H. Sigel
Eur. J. Inorg. Chem. 1781-1786 (1999)

Why is the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine in Its Diphosphorylated Form (PMEApp^4-) Initially a Better Substrate for Polymerases than (2'-Deoxy)adenosine 5'-Triphosphate (dATP^4-/ATP^4-)? Considerations on the Mechanism of Polymerase
H. Sigel, B. Song, C. A. Blindauer, L. E. Kapinos, F. Gregáň, and N. Prónayová
Chem. Commun., 743-744 (1999)

Effects of (N7)-Coordinated Nickel(II), Copper(II) or Platinum(II) on the Acid-Base Properties of Guanine Derivatives and Other Related Purines
B. Song, J. Zhao, R. Griesser, C. Meiser, H. Sigel, and B. Lippert
Chem. Eur. J. 5, 2374-2387 (1999)

Metal Ion-Binding Properties of the Nucleotide Analogue 1-[2-(Phosphonomethoxy)ethyl]cytosine (PMEC) in Aqueous Solution
C. A. Blindauer, A. Holý, and H. Sigel
Coll. Czech. Chem. Commun. 64, 613-632 (1999)

Acid-Base and Metal Ion-Coordinating Properties of Benzimidazole and Derivatives (= 1,3-Dideazapurines) in Aqueous Solution: Interrelation between Complex Stability and Ligand Basicity
L. E. Kapinos, B. Song, and H. Sigel
Chem. Eur. J. 5,1794-1802 (1999)https://doi.org/10.1039/A808479C

Extent of Intramolecular Stacking Interactions in the Mixed-Ligand Complexes Formed in Aqueous Solution by Copper(II), 2,2'-Bipyridine or 1,10-Phenanthroline and 2'-Deoxyguanosine 5'-Monophosphate. (Ternary Complexes in Solution. Part 62)
M. S. Lüth, L. E. Kapinos, B. Song, B. Lippert, and H. Sigel
J. Chem. Soc., Dalton Trans., 357-365 (1999)

Acid-Base and Metal Ion-Coordinating Properties of Pyrimidine-Nucleoside 5'-Diphosphates (CDP, UDP, dTDP) and of Several Simple Diphosphate Monoesters. Establishment of Relations between Complex Stability and Diphosphate Basicity
S. A. A. Sajadi, B. Song, F. Gregáň, and H. Sigel
Inorg. Chem. 38, 439-448 (1999)

1998

Quantification of Outer-Sphere Macrochelate Formation in the Ternary cis-Diammine-Platinum(II)-Bis-2'-Deoxyguanosine 5'-Monophosphate Complex, cis-(NH3)2Pt(dGMP)2^2-, and Formation of Quaternary Mixed Metal Ion Species with Magnesium(II), Copper(II) or Zinc(II) in Aqueous Solution
B. Song, G. Oswald, J. Zhao, B. Lippert, and H. Sigel
Inorg. Chem. 37, 4857-4864 (1998)https://doi.org/10.1007/s007750050252

Magnesium Complexes of the Antiviral 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) and of Its 1-, 3-, and 7-Deaza Analogues in Aqueous Solution
C. A. Blindauer, A. Holý, H. Dvořáková, and H. Sigel
J. Biol. Inorg. Chem. 3, 423-433 (1998)

Facilitation of the Copper(II)-Promoted Dephosphorylation of Adenosine 5'-Triphosphate (ATP^4-) by the Antiviral Nucleotide Analogue, 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)
H. Sigel, C. A. Blindauer, A. Holý, and H. Dvořáková
Chem. Commun., 1219-1220 (1998)https://doi.org/10.1007/s007750050227

Cis-Diammine-Platinum(II) Forms a Macrochelate with 2'-Deoxycytidine 5'-Monophosphate (dCMP^2-)! Reactivity and Acid-Base Properties of cis-(NH₃)₂Pt(dCMP)
G. Oswald, I. Rombeck, B. Song, H. Sigel, and B. Lippert
J. Biol. Inorg. Chem. 3, 236-245 (1998)

Ternary Complexes in Solution (Part 60). Intramolecular Stacking Interactions in Mixed Ligand Complexes Formed by Copper(II), 2,2'-Bipyridyl or 1,10-Phenanthroline and a Pyrimidine-Nucleoside 5'-Diphosphate (CDP^3–, UDP^3–, dTDP^3–)
S. A. A. Sajadi, B. Song, and H. Sigel
Inorg. Chim. Acta 283, 193-201 (1998) – Invited contribution to the issue dedicated to Prof. Osamu Yamauchion the occasion of his 60th birthday

Acid-Base and Metal Ion-Binding Properties of the Quaternary Complex, cis-(NH₃)₂Pt(dGuo)(dGMP), Formed Between cis-Diammineplatinum(II), 2'-Deoxyguanosine (dGuo) and 2'-Deoxyguanosine 5'-Monophosphate (dGMP^2–) in Aqueous Solution
H. Sigel, B. Song, G. Oswald, and B. Lippert
Chem. Eur. J. 4, 1053-1060 (1998)

Review

The Effects of N7-Coordinated cis-Diammine-Platinum(II) on the Acid-Base Properties of Guanine Derivatives
H. Sigel and B. Lippert
Pure Appl. Chem. 70, 845-854 (1998)

Metal Ion-Coordinating Properties of Imidazole and Derivatives in Aqueous Solution. Interrelation Between Complex Stability and Ligand Basicity
L. E. Kapinos, B. Song, and H. Sigel
Inorg. Chim. Acta 280, 50-56 (1998) – Invited contribution to the issue dedicated to the 'Memory of Professor Mark E. Vol'pin'

Review

Metal Ion-Assisted Stacking Interactions and the Facilitated Hydrolysis of Nucleoside 5'-Triphosphates
H. Sigel
Pure Appl. Chem. 70, 969-976 (1998)

1997

Ternary Complexes in Solution (Part 61). Intramolecular Hydrophobic and Stacking Interactions in Mixed Ligand Complexes Formed by Copper(II), 2,2'-Bipyridyl or 1,10-Phenanthroline, and n-Butyl Diphosphate (BuDP^3-) or Phenyl Diphosphate (PhDP^3-)
S. A. A. Sajadi, B. Song, F. Gregáň, and H. Sigel
Bull Chem. Soc. Ethiopia 11, 121-130 (1997) – Contribution on the occasion of the 10th Anniversary of the Bulletin of the Chemical Society of Ethiopia

Review

On the Metal Ion-Coordinating Properties of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine and Related Compounds
H. Sigel
J. Indian Chem. Soc. 74, 261-271 (1997) – Invited contribution connected with the receipt of the P. Ray Award for the year 1996 from the Indian Chemical Society

Complex Formation of the Antiviral 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) and of Its N1, N3, and N7 Deaza Derivatives with Copper(II) in Aqueous Solution
C. A. Blindauer, A. H. Emwas, A. Holý, H. Dvořáková, E. Sletten, and H. Sigel
Chem. Eur. J. 3, 1526-1536 (1997)

Extent of Intramolecular Aromatic-ring Stacking in Ternary Cu²⁺ Complexes Formed by 2,2'-Bipyridyl or 1,10-Phenanthroline and Flavin Mononucleotide (FMN^2–). (Ternary Complexes in Solution. Part 58)
M. Bastian and H. Sigel
Inorg. Chem. 36, 1619-1624 (1997)

Solution Properties of Antiviral Adenine-Nucleotide Analogues. The Acid-Base Properties of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) and of Its N1,N3, and N7 Deaza Derivatives in Aqueous Solution
C. A. Blindauer, A. Holý, H. Dvořáková, and H. Sigel
J.C.S. Perkin Trans. 2, 2353-2363 (1997)

The N3 Position of N9-Substituted Adenine as a Metal Ion Binding Site: Structural and Solution Studies with Pd^IIand Pt^II Complexes of N6',N6',N9-Trimethyladenine
C. Meiser, B. Song, E. Freisinger, M. Peilert, H. Sigel, and B. Lippert
Chem. Eur. J. 3, 388-398 (1997)

Stabilities and Structures of Metal Ion Complexes of Adenosine 5'-O-Thiomonophosphate (AMPS^2–) in Comparison with Those of Its Parent Nucleotide (AMP^2–) in Aqueous Solution
R. K. O. Sigel, B. Song, and H. Sigel
J. Am. Chem. Soc. 119, 744-755 (1997)

Acid-Base Properties of Adenosine 5'-O-Thiomonophosphate in Aqueous Solution
B. Song, R. K. O. Sigel, and H. Sigel
Chem. Eur. J. 3, 29-33 (1997)

1996

The Assisted Self-Association of ATP^4–by a Poly(amino acid) [poly(Lys)] and Its Significance for Cell Organelles that Contain High Concentrations of Nucleotides
H. Sigel and N. A. Corfù
Eur. J. Biochem. 240, 508-517 (1996)

Review

Stacking Interactions Involving Nucleotides and Metal Ion Complexes
O. Yamauchi, A. Odani, H. Masuda, and H. Sigel
Met. Ions Biol. Syst. 32, 207-270 (1996)

Review

Solution Structures of Nucleotide Metal Ion Complexes. Isomeric Equilibria
H. Sigel and B. Song
Met. Ions Biol. Syst. 32, 135-205 (1996)

1995

Acid-Base and Metal Ion-Binding Properties of Flavin Mononucleotide (FMN^2–). Is a 'Dielectric' Effect Responsible for the Increased Complex Stability?
H. Sigel, B. Song, G. Liang, R. Halbach, M. Felder, and M. Bastian
Inorg. Chim. Acta 240, 313-322 (1995) – Invited contribution to the issue dedicated to Professor Fred Basoloon the occasion of his 75th birthday

Review

Intramolecular Equilibria in Metal Ion Complexes of Artificial Nucleotide Analogues with Antiviral Properties. A Case Study
H. Sigel
Coord. Chem. Rev. 144, 287-319 (1995) – Invited contribution to this special 'Bioinorganic Issue' of CCR

Review

Complexes of Metal Ions with Various Nucleic Acid Components
H. Sigel in Handbook of Metal-Ligand Interactions in Biological Fluids, Volume I: Bioinorganic Chemistry, G. Berthon, Ed., Marcel Dekker, Inc., New York, Basel, Hong Kong, 1995, pp. 451-465

1994

Metal-Ion-Coordinating Propertiesof a Viral Inhibitor, a Pyrophosphate Analogue, and a Herbicide Metabolite, a Glycinate Analogue: The Solution Properties of the Potentially Five-Membered Chelates Derived from Phosphonoformic Acid and (Aminomethyl)phosphonic Acid
B. Song, D. Chen, M. Bastian, R. B. Martin, and H. Sigel
Helv. Chim. Acta 77, 1738-1756 (1994)

Comparison of the Extent of Macrochelate Formation in Complexes of Divalent Metal Ions with Guanosine (GMP^2–), Inosine (IMP^2–), and Adenosine 5'-Monophosphate (AMP^2–). The Crucial Role of N-7 Basicity in Metal Ion-Nucleic Base Recognition
H. Sigel, S. S. Massoud, and N. A. Corfù
J. Am. Chem. Soc. 116, 2958-2971 (1994)

Review

The Colourless 'Chameleon' or the Peculiar Properties of Zn²⁺ in Complexes in Solution. Quantification of Equilibria Involving a Change of the Coordination Number of the Metal Ion
H. Sigel and R. B. Martin
Chem. Soc. Rev. 23, 83-91 (1994)

1993

Review

Interactions of Metal Ions with Nucleotides and Nucleic Acids and their Constituents
H. Sigel
Chem. Soc. Rev. 22, 255-267 (1993)

1992

Metal-Ion-Coordinating Properties of Various Phosphonate Derivatives, Including 9-[2-(Phosphonylmethoxy)ethyl]adenine (PMEA) - an Adenosine Monophosphate (AMP) Analogue with Antiviral Properties
H. Sigel, D. Chen, N. A. Corfù, F. Gregáň, A. Holý, and M. Strašák
Helv. Chim. Acta 75, 2634-2656 (1992)

Review

Have Adenosine 5'-Triphosphate (ATP^4–) and Related Purine-Nucleotides Played a Role in Early Evolution? ATP, Its Own 'Enzyme' in Metal Ion Facilitated Hydrolysis!
H. Sigel
Inorg. Chim. Acta198-200, 1-11 (1992) – Invited contribution to this 'Jubilee issue 200'

Metal Ion Binding Properties of Dihydroxyacetone Phosphate and Glycerol 1-Phosphate
G. Liang, D. Chen, M. Bastian, and H. Sigel
J. Am. Chem. Soc. 114, 7780-7785 (1992)

Review

On the Dichotomy of Metal Ion Binding in Adenosine Complexes
H. Sigel, N. A. Corfù, L.-n. Ji, and R. B. Martin
Comments Inorg. Chem. 13, 35-59 (1992)

1991

Comments on Potentiometric pH Titrations and the Relationship between pH-Meter Reading and Hydrogen Ion Concentration
H. Sigel, A. D. Zuberbühler, and O. Yamauchi
Anal. Chim. Acta 255, 63-72 (1991)

Acid-base Properties of Nucleosides and Nucleotides as a Function of Concentration. Comparison of the Proton Affinity of the Nucleic Base Residues in the Monomeric and Self-Associated, Oligomeric 5'-Triphosphates of Inosine (ITP), Guanosine (GTP), and Adenosine (ATP)
N. A. Corfù and H. Sigel
Eur. J. Biochem. 199, 659-669 (1991)

Review

Chemistry of Metals in Biological Systems
H. Sigel
COMMUNICATIONS. The Journal of the European Science Foundation, No. 24, 16-17 (1991) – Invited contribution

1990

Comparison of the Self-Association Properties of the 5'-Triphosphates of Inosine (ITP), Guanosine (GTP), and Adenosine (ATP). Further Evidence for Ionic Interactions in the Highly Stable Dimeric [H₂(ATP)]₂^4–Stack
N. A. Corfù, R. Tribolet, and H. Sigel
Eur. J. Biochem. 191, 721-735 (1990)

Synergism Between Different Metal Ions in the Dephosphorylation of Adenosine 5'-Triphosphate (ATP) in Mixed Metal Ion/ATP Systems, and Influence of a Decreasing Solvent Polarity (Dioxane-Water Mixtures) on the Dephosphorylation Rate. Effects of Mg²⁺, Na⁺ and NH₄⁺ Ions. (Hydrolysis of Nucleoside Phosphates. Part 11)
H. Sigel and R. Tribolet
J. Inorg. Biochem. 40, 163-179 (1990)

Metal-Ion-Governed Molecular Recognition: Extent of Intramolecular Stack Formation in Mixed-Ligand Copper(II) Complexes Containing a Heteroaromatic N Base and an Adenosine Monophosphate (2'-AMP, 3'-AMP, or 5'-AMP). A Structuring Effect of the Metal-Ion Bridge. (Ternary Complexes in Solution. Part 52)
S. S. Massoud, R. Tribolet, and H. Sigel
Eur. J. Biochem. 187, 387-393 (1990)

Review

The Imidazole Group and Its Stacking Properties in Mixed Ligand Metal Ion Complexes
H. Sigel, R. Tribolet, and O. Yamauchi
Comments Inorg. Chem. 9, 305-330 (1990)

Review

Mechanistic Aspects of the Metal Ion Promoted Hydrolysis of Nucleoside 5'-Triphosphates (NTPs)
H. Sigel
Coord. Chem. Rev. 100, 453-539 (1990) – Invited contribution to this 'Jubilee issue 100'

1989

Review

Metal-Nucleotide Interactions
H. Sigel in "Metal-DNA Chemistry", ed. by T. D. Tullius; published by the American Chemical Society, Washington, D.C.; ACS Symp. Series 402, 159-204 (1989)

Review

Self-Association of Nucleotides. Effects of Protonation and Metal Ion Coordination
H. Sigel
Biol. Trace Element Res. 21, 49-59 (1989) – This publication was translated into Chinese by Professor JI Liang-nian: Zhongshan University Chemistry6, 26-30 (1991)

Evaluation of the Metal-Ion-Coordinating Differences Between the 2'-, 3'-and 5'-Monophosphates of Adenosine
S. S. Massoud and H. Sigel
Eur. J. Biochem. 179, 451-458 (1989)

Review

Hydrophobic Interactions in Biological Systems: Some Background Information Based on Ligand-Ligand Interactions in Metal Ion Complexes
H. Sigel
Pure Appl. Chem. 61, 923-932 (1989)

1988

Comparison of the Metal Ion Coordinating Properties of Tubercidin 5'-Monophosphate (7-Deaza-AMP) with Those of Adenosine 5'-Monophosphate (AMP) and 1,N⁶-Etheno-adenosine 5'-Monophosphate (ε-AMP). Definite Evidence for Metal Ion-Base Backbinding to N-7 and Extent of Macrochelate Formation in M(AMP) and M(ε-AMP)
H. Sigel, S. S. Massoud, and R. Tribolet
J. Am. Chem. Soc. 110, 6857-6865 (1988)

Review

Quantification of Intramolecular Ligand Equilibria in Metal-Ion Complexes
R. B. Martin and H. Sigel
Comments Inorg. Chem. 6, 285-314 (1988)

1987

Isomeric Equilibria in Complexes of Adenosine 5'-Triphosphate with Divalent MetalIons. Solution Structures of M(ATP)^2–Complexes
H. Sigel
Eur. J. Biochem. 165, 65-72 (1987)

Review

Self-Association, Protonation, and Metal-Coordination of 1,N⁶-Ethenoadenine Derivatives in Comparison with Their Parent Compounds Adenosine, AMP and ATP
H. Sigel
Chimia 41, 11-26 (1987)

1985

An Estimation of the Equivalent Solution Dielectric Constant in the Active-Site Cavity of Metalloenzymes. Dependence of Carboxylate-Metal-Ion Complex Stabilities on the Polarity of Mixed Aqueous/Organic Solvents
H.Sigel, R. B. Martin, R. Tribolet, U. K. Häring, and R. Malini-Balakrishnan
Eur. J. Biochem. 152, 187-193 (1985)

Ternary Complexes in Solution (Part 48). Influence of Organic Solvents on Intramolecular Aromatic-Ring Stacks in Aqueous Mixed-Ligand Metal Ion Complexes. Opposing Solvent Effects
H. Sigel, R. Malini-Balakrishnan, and U. K. Häring
J. Am. Chem. Soc. 107, 5137-5148 (1985)

1984

General Considerations on Transphosphorylations: Mechanism of the Metal Ion Facilitated Dephosphorylation of Nucleoside 5'-Triphosphates, Including Promotion of ATP Dephosphorylation by Addition of Adenosine 5'-Monophosphate. (Hydrolysis of Nucleoside Phosphates. Part 8)
H. Sigel, F. Hofstetter, R. B. Martin, R. M. Milburn, V. Scheller-Krattiger, and K. H. Scheller
J. Am. Chem. Soc. 106, 7935-7946 (1984)

1983

Review

Comparison of the Metal Ion Promoted Dephosphorylation of Adenosine 5'-Triphosphate and Uridine 5'-Triphosphate
H. Sigel
Pure Appl. Chem. 55, 137-144 (1983)

1982

Review

Coordinating Properties of the Amide Bond. Stability and Structure of Metal Ion Complexes of Peptides and Related Ligands
H. Sigel and R. B. Martin
Chem. Rev. 82, 385-426 (1982) – This review is among 'The 1982 Chemistry Articles Most Cited in 1982-1984'; see E. Garfield, Current Contents; Physical, Chemical & Earth Sciences 25, No 51-52, pp 3-17 (1985)

Review

(a) Die hydrophoben und Metallionen-koordinierenden Eigenschaften von α-Liponsäure -ein Beispiel für intramolekulare Gleichgewichte in Metallionen-Komplexen
H. Sigel
Angew. Chemie 94, 421-432 (1982)
(b) The Hydrophobic and Metal-Ion Coordinating Properties of α-Lipoic Acid -An Example of Intramolecular Equilibria in Metal-Ion Complexes
H. Sigel
Angew. Chemie, Internat. Edit. Engl. 21, 389-400 (1982)

1981

Review

The Coordinating Properties of d-Biotin
H. Sigel
Experientia 37, 789-798 (1981)

Macrochelate Formation in Monomeric Metal Ion Complexes of Nucleoside 5'-Triphosphates and the Promotion of Stacking by Metal Ions. Comparison of the Self-Association of Purine and Pyrimidine 5'-Triphosphates Using Proton Nuclear Magnetic Resonance
K. H. Scheller, F. Hofstetter, P. R. Mitchell, B. Prijs, and H. Sigel
J. Am. Chem. Soc. 103, 247-260 (1981)

1980

Review

Stability, Structure and Reactivity of Mixed Ligand Complexes in Solution
H. Sigel in "Coordination Chemistry -20", ed. by D. Banerjea, published by IUPAC through Pergamon Press, Oxford and New York, 1980, pp. 27-45

Ternary Complexes in Solution. 35. Intramolecular Hydrophobic Ligand-Ligand Interactions in Mixed Ligand Complexes Containing an Aliphatic Amino Acid
B. E. Fischer and H. Sigel
J. Am. Chem. Soc. 102, 2998-3008 (1980)

Metal Ion/Buffer Interactions. 2. Stability of Binary and Ternary Complexes Containing 2-[Bis(2-hydroxyethyl)amino]-2(hydroxymethyl)-1,3-propanediol (Bis-Tris) and Adenosine 5'-Triphosphate (ATP)
K. H. Scheller, T. H. J. Abel, P. E. Polanyi, P. K. Wenk, B. E. Fischer, and H. Sigel
Eur. J. Biochem. 107, 455-466 (1980)

Discriminating and Stability Increasing Properties of the Imidazole Moiety in Mixed-Ligand Complexes. (Ternary Complexes in Solution. Part 34)
H. Sigel
Inorg. Chem. 19, 1411-1413 (1980)

1979

Metal Ions and Hydrogen Peroxide (Part 32). Catalase-like Activity of Cu²⁺ in Aqueous Solution and Its Promotion by the Coordination of 2,2'-Bipyridyl
H. Sigel, K. Wyss, B. E. Fischer, and B. Prijs
Inorg. Chem. 18, 1354-1358 (1979)

Metal Ion/Buffer Interactions. Stability of Binary and Ternary Complexes Containing 2-Amino-2-(hydroxymethyl)-1,3-propanediol (Tris) and Adenosine 5'-Triphosphate (ATP)
B. E. Fischer, U. K. Häring, R. Tribolet, and H. Sigel
Eur. J. Biochem. 94, 523-530 (1979)

Review

The Ambivalent Properties of Some Base-Modified Nucleotides
H. Sigel
Met. Ions Biol. Syst. 8, 125-158 (1979)

1977

Review

Biological Implications from the Stability of Ternary Complexes in Solution. Mixed-Ligand Complexes with Manganese(II) and Other 3d-Ions. (Ternary Complexes in Solution. Part 27)
H. Sigel, B. E. Fischer, and B. Prijs
J. Am. Chem. Soc. 99, 4489-4496 (1977)

1976

Ternary Complexes in Solution. XXIV. Metal Ion Bridging of Stacked Purine-Indole Adducts. The Mixed-Ligand Complexes of Adenosine 5'-Triphosphate, Tryptophan, and Manganese(II), Copper(II), or Zinc(II)
H. Sigel and C. F. Naumann
J. Am. Chem. Soc. 98, 730-739 (1976)

1975

Review

(a) Stabilität, Struktur und Reaktivität von ternären Cu²⁺-Komplexen
H. Sigel
Angew. Chemie 87, 391-400 (1975)
(b) Ternary Cu²⁺ Complexes: Stability, Structure and Reactivity
H. Sigel
Angew. Chemie, Internat. Edit. Engl. 14, 394-402 (1975)
(c) The English version of this publication was translated into Hungarian upon the request of the "Commission of Coordination Chemistry of the Hungarian Academy of Sciences": Kémiai Köszlemények 46, 287-308 (1976)

1974

Ternary Complexes in Solution. XVIII. The Stability-Enhancement of Nucleotide-Containing Charge-Transfer Adducts through the Formation of a Metal Ion Bridge
C. F. Naumann and H. Sigel
J. Am. Chem. Soc. 96, 2750-2756 (1974)

1973

Review

Structural Aspects of Mixed-Ligand Complex Formation in Solution
H. Sigel
Met. Ions Biol. Syst. 2, 63-125 (1973)

Review

Metal Ion-Thioether Interactions of Biological Interest
D. B. McCormick, R. Griesser, and H. Sigel
Met. Ions Biol. Syst. 1, 213-247 (1974)

1970

Review

Discriminating Behavior of Metal Ions and Ligands with Regard to Their Biological Significance
H. Sigel and D. B. McCormick
Accounts Chem. Res. 3, 201-208 (1970)

1969

Metal Ion Complexes with Biotin and Biotin Derivatives. Participation of Sulfur in the Orientation of Divalent Cations
H. Sigel, D. B. McCormick, R. Griesser, B. Prijs, and L. D. Wright
Biochemistry 8, 2687-2695 (1969)

Review

(a) Zur katalatischen und peroxidatischen Aktivität von Cu²⁺-Komplexen
H. Sigel
Angew. Chemie 81, 161-171 (1969)
(b) Catalase and Peroxidase Activity of Cu²⁺ Complexes
H. Sigel
Angew. Chemie, Internat. Edit. Engl. 8, 167-177 (1969)

1968

Metallionen und H₂O₂ (15. Mitteilung). Die Denaturierung von DNA in Abhängigkeit vom pH-Einfluss von Metallionen
H. Erlenmeyer, R. Griesser, B. Prijs und H. Sigel
Biochim. Biophys. Acta 157, 637-640 (1968)

1967

Review

Ternäre Komplexe in Lösung (Dem Andenken an Prof. H. Erlenmeyer gewidmet)
H. Sigel
Chimia 21, 489-500 (1967)

1965

Review

Zur Wandlung des Begriffs der Aromatizität
A. Courtin und H. Sigel
Chimia 19, 407-415 (1965)

1963

Metallionen-Komplexe von 2-Aminopyridin-1-oxid. I. Komplexe mit dem Liganden in seiner Neutralform
H. Sigel und H. Brintzinger
Helv. Chim. Acta 46, 701-712 (1963)

"Metal Ions in Biological Systems" and "Metal Ions in Life Sciences"

"Metal Ions in Life Sciences" links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, biophysics, enzymology, environmental chemistry, physiology, toxicology, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields, as well as teachers preparing courses, e.g., in Bioinorganic Chemistry.

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