Publications
Vanella, R. et al. (2024) “Understanding activity-stability tradeoffs in biocatalysts by enzyme proximity sequencing”, Nature Communications, 15(1). Available at: 10.1038/s41467-024-45630-3.
Yang, B. et al. (2024) “Engineering the Mechanical Stability of a Therapeutic Complex between Affibody and Programmed Death-Ligand 1 by Anchor Point Selection”, ACS Nano, 18(46), pp. 31912–31922. Available at: 10.1021/acsnano.4c09220.
Heiniger, M. et al. (2024) “Functionalized Polysaccharides Improve Sensitivity of Tyramide/Peroxidase Proximity Labeling Assays through Electrostatic Interactions”, ACS Biomaterials Science and Engineering, 10(9), pp. 5869–5880. Available at: 10.1021/acsbiomaterials.4c00895. edoc
Gomes, D.E.B. et al. (2024) “Integrating Dynamic Network Analysis with AI for Enhanced Epitope Prediction in PD-L1:Affibody Interactions”, Journal of the American Chemical Society, 146(34), pp. 23842–23853. Available at: 10.1021/jacs.4c05869.
Liu, Z. et al. (2024) “Engineering an artificial catch bond using mechanical anisotropy”, Nature Communications, 15(1). Available at: 10.1038/s41467-024-46858-9.
Kueng, C. et al. (2024) “Decoding Stability and Epistasis in Human Myoglobin by Deep Mutational Scanning and Codon-level Machine Learning”. Cold Spring Harbor Laboratory (Biorxiv). Available at: 10.1101/2024.02.24.581358.
Heiniger, M. et al. (2024) “Functionalized polysaccharides improve sensitivity of tyramide/peroxidase proximity labeling assays through electrostatic interactions”. Cambridge University Press (ChemRXiv). Available at: 10.26434/chemrxiv-2024-crr79.
Zarah, W.-K., Michael, A.N. (2023) “CatchGel—A Molecular to Macroscale Investigation of Catch Bond-Crosslinked Polysaccharide Hydrogels”, in 2022 MRS Fall Meeting. Virtuell.
Vanella, R. et al. (2023) “Understanding Activity-Stability Tradeoffs in Biocatalysts by Enzyme Proximity Sequencing”. Cold Spring Harbor Laboratory (Biorxiv). Available at: 10.1101/2023.02.24.529916.
Küng, C., Vanella, R., Nash, M.A. (2023) “Directed evolution of Rhodotorula gracilisd-amino acid oxidase using single-cell hydrogel encapsulation and ultrahigh-throughput screening”, Reaction Chemistry and Engineering, (8), pp. 1960–1968. Available at: 10.1039/d3re00002h. edoc | Open Access
Liu, Z. et al. (2022) “Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex”, Nano Letters, 22(1), pp. 179–187. Available at: 10.1021/acs.nanolett.1c03584. edoc | Open Access
Vanella, R. et al. (2022) “High-throughput screening, next generation sequencing and machine learning: advanced methods in enzyme engineering”, Chemical Communications, 58(15), pp. 2455–2467. Available at: 10.1039/d1cc04635g. edoc | Open Access
Risser, F. et al. (2022) “Engineered Molecular Therapeutics Targeting Fibrin and the Coagulation System: a Biophysical Perspective”, Biophysical reviews, 14(2), pp. 427–461. Available at: 10.1007/s12551-022-00950-w. edoc | Open Access
Santos, M.S. et al. (2022) “Correlating single-molecule rupture mechanics with cell population adhesion by yeast display”, Biophysical reports, 2(1), p. None. Available at: 10.1016/j.bpr.2021.100035. edoc | Open Access
Risser, F., López-Morales, J., Nash, M.A. (2022) “Adhesive Virulence Factors of Staphylococcus aureus Resist Digestion by Coagulation Proteases Thrombin and Plasmin”, ACS Bio & Med Chem Au, 2(6), pp. 586–599. Available at: 10.1021/acsbiomedchemau.2c00042. edoc | Open Access
Nash, M.A. (2022) “Elastin-like Polypeptides: Protein-based Polymers for Biopharmaceutical Development”, Chimia, 76(5), pp. 478–479. Available at: 10.2533/chimia.2022.478. edoc | Open Access
Liu, H. et al. (2022) “Optimal Sacrificial Domains in Mechanical Polyproteins: S. epidermidis Adhesins Are Tuned for Work Dissipation”, JACS Au, 2(6), pp. 1417–1427. Available at: 10.1021/jacsau.2c00121. edoc | Open Access
Huo, Z. et al. (2021) “Metastatic Esophageal Carcinoma Cells Exhibit Reduced Adhesion Strength and Enhanced Thermogenesis”, Cells, 10(5), p. 1213. Available at: 10.3390/cells10051213. edoc | Open Access
Nash, M.A. (2021) “Scalable Online Learning in Physical Chemistry”, Chimia, 75(1), pp. 64–66. Available at: 10.2533/chimia.2021.64. edoc | Open Access
Urosev, I., Lopez Morales, J., Nash, M.A. (2020) “Phase Separation of Intrinsically Disordered Protein Polymers Mechanically Stiffens Fibrin Clots”, Advanced Functional Materials, 30(51), p. 2005245. Available at: 10.1002/adfm.202005245. edoc | Open Access
Jensen, M.H. et al. (2020) “Stochastic ordering of complexoform protein assembly by genetic circuits”, PLoS Computational Biology, 16(6), p. e1007997. Available at: 10.1371/journal.pcbi.1007997. edoc | Open Access
Nash, M.A. (2020) “Single-molecule and Single-cell Approaches in Molecular Bioengineering”, Chimia, 74(9), pp. 704–709. Available at: 10.2533/chimia.2020.704. edoc | Open Access
Liu, Z. et al. (2020) “High force catch bond mechanism of bacterial adhesion in the human gut”, Nature Communications, 11(1), p. 4321. Available at: 10.1038/s41467-020-18063-x. edoc | Open Access
Yang, B. et al. (2020) “Influence of Fluorination on Single-Molecule Unfolding and Rupture Pathways of a Mechanostable Protein Adhesion Complex”, Nano Letters, 20(12), pp. 8940–8950. Available at: 10.1021/acs.nanolett.0c04178. edoc | Open Access
Nash, M.A. (2020) “Zig Zag AFM Protocol Reveals New Intermediate Folding States of Bacteriorhodopsin”, Biophysical journal, 118(3), pp. 538–540. Available at: 10.1016/j.bpj.2019.12.004. edoc | Open Access
Yang, B. et al. (2020) “Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes”, Frontiers in Molecular Biosciences, 7, p. 85. Available at: 10.3389/fmolb.2020.00085. edoc | Open Access
Vanella, R. et al. (2019) “Genetically encoded stimuli-responsive cytoprotective hydrogel capsules for single cells provide novel genotype-phenotype linkage”, Chemistry of Materials, 31(6), pp. 1899–1907. Available at: 10.1021/acs.chemmater.8b04348. edoc | Open Access
Vanella, R., Ta, D.T., Nash, M.A. (2019) “Enzyme-mediated hydrogel encapsulation of single cells for high-throughput screening and directed evolution of oxidoreductases”, Biotechnology and bioengineering, 116(8), pp. 1878–1886. Available at: 10.1002/bit.27002. edoc | Open Access
Nash, M.A., Liu, H., Schittny, V. (2019) “Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex”, Nano letters, 19(8), pp. 5524–5529. Available at: 10.1021/acs.nanolett.9b02062. edoc | Open Access
Bernardi, R.C. et al. (2019) “Mechanisms of Nanonewton Mechanostability in a Protein Complex Revealed by Molecular Dynamics Simulations and Single-Molecule Force Spectroscopy”, Journal of the American Chemical Society, 141(37), pp. 14752–14763. Available at: 10.1021/jacs.9b06776. edoc | Open Access
Liu, H., Ta, D.T., Nash, M.A. (2018) “Mechanical Polyprotein Assembly Using Sfp and Sortase‐Mediated Domain Oligomerization for Single‐Molecule Studies”, Small Methods, 2(6), p. 1800039. Available at: 10.1002/smtd.201800039. edoc | Open Access
Ta, D.T., Vanella, R., Nash, M.A. (2018) “Bioorthogonal Elastin-like Polypeptide Scaffolds for Immunoassay Enhancement”, ACS Applied Materials and Interfaces, 10(36), pp. 30147–30154. Available at: 10.1021/acsami.8b10092. edoc | Open Access
Gunnoo, M. et al. (2018) “Steered molecular dynamics simulations reveal the role of Ca2+ in regulating mechanostability of cellulose-binding proteins”, Physical Chemistry Chemical Physics, 20(35), pp. 22674–22680. Available at: 10.1039/c8cp00925b. edoc | Open Access
Lewis, D.D. et al. (2018) “Engineered Stochastic Adhesion Between Microbes as a Protection Mechanism Against Environmental Stress”, Cellular and Molecular Bioengineering, 11(5), pp. 367–382. Available at: 10.1007/s12195-018-0552-9. edoc
Milles, L.F. et al. (2017) “Mechanical Stability of a High-Affinity Toxin Anchor from the Pathogen Clostridium perfringens”, Journal of Physical Chemistry B, 121(15), pp. 3620–3625. Available at: 10.1021/acs.jpcb.6b09593. edoc | Open Access
Ott, W. et al. (2017) “Single-molecule force spectroscopy on polyproteins and receptor-ligand complexes: The current toolbox”, Journal of Structural Biology, 197(1), pp. 3–12. Available at: 10.1016/j.jsb.2016.02.011. edoc
Durner, E. et al. (2017) “Post-translational Sortase-mediated Attachment of High-strength Force Spectroscopy Handles”, ACS Omega, 2(6), pp. 3064–3069. Available at: 10.1021/acsomega.7b00478. edoc | Open Access
Ta, D.T., Vanella, R., Nash, M.A. (2017) “Magnetic Separation of Elastin-like Polypeptide Receptors for Enrichment of Cellular and Molecular Targets”, Nano Letters, 17(12), pp. 7932–7939. Available at: 10.1021/acs.nanolett.7b04318. edoc | Open Access
Verdorfer, T. et al. (2017) “Combining in Vitro and in Silico Single-Molecule Force Spectroscopy to Characterize and Tune Cellulosomal Scaffoldin Mechanics”, Journal of the American Chemical Society, 139(49), pp. 17841–17852. Available at: 10.1021/jacs.7b07574. edoc | Open Access
Ott, W. et al. (2017) “Elastin-like Polypeptide Linkers for Single-Molecule Force Spectroscopy”, ACS Nano, 11(6), pp. 6346–6354. Available at: 10.1021/acsnano.7b02694. edoc | Open Access
Malinowska, K.H., Nash, M.A. (2016) “Enzyme- and affinity biomolecule-mediated polymerization systems for biological signal amplification and cell screening”, Current Opinion in Biotechnology, 39, pp. 68–75. Available at: 10.1016/j.copbio.2016.01.007. edoc
Ott, W. et al. (2016) “Sequence-Independent Cloning and Post-Translational Modification of Repetitive Protein Polymers through Sortase and Sfp-Mediated Enzymatic Ligation”, Biomacromolecules, 17(4), pp. 1330–8. Available at: 10.1021/acs.biomac.5b01726. edoc | Open Access
Nash, M.A. et al. (2016) “Single versus dual-binding conformations in cellulosomal cohesin-dockerin complexes”, Current Opinion in Structural Biology, 40, pp. 89–96. Available at: 10.1016/j.sbi.2016.08.002. edoc
Nash, M.A., Shoseyov, O. (2016) “Editorial overview: Nanobiotechnology at a crossroads: moving beyond proof of concept”, Current Opinion in Biotechnology, 39, p. vii-ix. Available at: 10.1016/j.copbio.2016.04.024. edoc
Schoeler, C. et al. (2016) “Biasing effects of receptor-ligand complexes on protein-unfolding statistics”, Physical review E, 94(4-1), p. 042412. Available at: 10.1103/physreve.94.042412. edoc | Open Access